Did you know Epichem Pty Ltd is experienced in working with PMO’s and offers custom synthesis services for the preparation of PMO conjugates? PMO’s (Phosphorodiamidate Morpholino Oligonucleotides, or “morpholino oligomers”) are nucleic acid analogues used to modify gene expression and are being developed as pharmaceutical therapeutics to target genetic diseases and pathogenic organisms such as bacteria or viruses. Several PMO-based therapeutics have been approved by the FDA in the last few years including Golodirsen (Vyondys 53), Viltolarsen (Viltepso), and Casimersen (Amondys 45). Often PMO’s require help to traverse membranes and enter into tissues and cells where the desired target is located. PMO conjugates are the primary strategy to achieve effective delivery of PMO’s. Epichem Pty Ltd has developed expertise in the preparation and purification of PMO conjugates, including conjugates to cell-penetrating peptides (CPP’s) and specific tissue targeting motifs. We would love to help you accelerate your research and commercialization of this exciting technology.
