Medicinal Chemistry


Epichem delivers high quality medicinal and synthetic chemistry

services for drug discovery projects from hit assessment through to candidate nomination. We have a successful proven track record in delivering project milestones and this includes working with customers that are keen on a high impact, low maintenance team.

Epichem is a renowned Australian company working with partners worldwide. Behind the scenes, medicinal and synthetic chemists have contributed to a number of Australian and international biotech success stories and continue to make an impact on their drug discovery efforts.

We have made significant contributions to new compounds in pre-clinical and clinical trials and have experience in a broad range of disease indications including central nervous system disorders, oncology, HIV, Hepatitis C and infectious diseases.


Early-phase drug discovery

Our early-phase drug discovery expertise includes:

  • Molecule design and optimisation.
  • Synthesis of analogue libraries.
  • Hit to lead projects.
  • Lead optimisation towards candidate selection.
  • Creative problem solving.
  • Novel IP generation.
  • Project scoping and planning
  • Project management
  • Drug discovery consultancy
  • Seamless integration into multidisciplinary team


Synthesis services to support research & development

Our custom synthesis capability adds significant value to R&D outcomes.  Our services include:

  • Benchmark compounds for biological assays.
  • Drug conjugates, fluorescent tags and metabolites.
  • Deuterated and 13C labelled molecules – including metabolites for identification.
  • Scaffolds and intermediates.
  • Method development and route planning.
  • Analysis to your requirements including NMR, LCMS, GCMS, HPLC, IR and water content.
  • Design and synthesis of complex molecules.
  • Synthesis of heterocycles, alkaloids, macrocycles, peptides, deuterated compounds, chiral synthesis and much more.