Solubility has been a major hurdle for many ๐๐ซ๐ฎ๐ ๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ๐ฒ programs. Poor solubility of compounds can inherently impact on the quality of decision-making data which affects the following properties: โ Absorption โ Distribution โ Metabolism โ Excretion (ADME) โ Pharmacokinetic (PK)
Poor water solubility ultimately leads to low drug absorption and exposure. ๐๐๐
If your lead compound is suffering from low water solubility, Epichem can help. Epichem is highly experienced in improving water solubility through the preparation of various pro-drug derivatives including phosphates and sulfates.
